Domenico LIBRI (INSTITUT JACQUES MONOD – PARIS)
3 novembre 2020 11 h 00 min – 12 h 00 min
Philippe Jeanteur Seminar Room
Cellular life in times of pervasive transcription : a crowded environment for the expression and integrity of the genome
In the last ten years or so it has become clear that non-coding transcription largely occurs outside of annotated regions, generating the phenomenon known as pervasive transcription. Many non-canonical transcription units overlap bona fide genes, both in the sense and the antisense direction, generating non-coding RNAs the function of which is generally not established. Because the DNA is a crowded environment, the different machineries that read, replicate and repair the information stored must be coordinated to limit potentially disruptive interferences. We study in the yeast model the mechanisms that generate and control pervasive transcription and we are particularly interested in the relationships between non-coding transcription and other DNA-associated events, including replication.
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